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Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1)

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Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1)
CCC R365
HGNC 25207
MGI 1916278
RGD 1307700
UniProt Q8WV92
The last steps of multivesicular body (MVB) formation, human immunodeficiency virus (HIV)-1 budding and cytokinesis require a functional endosomal sorting complex required for transport (ESCRT) machinery to facilitate topologically equivalent membrane fission events. Increased sodium tolerance (IST) 1, a new positive modulator of the ESCRT pathway, has been described recently, but an essential function of this highly conserved protein has not been identified.
hIST1 conserved interaction with VPS4, CHMP1A/B, and LIP5. A microtubule interacting and transport (MIT) domain interacting motif (MIM) in hIST1 that is necessary for its interaction with VPS4, LIP5 and other MIT domain-containing proteins, namely, MITD1, AMSH, UBPY, and Spastin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Interacting And Transport Domain Containing Protein 1 (MITD1) ELISA Kit Customized Service Offer
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex."Genomics 88:333-346(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Essential role of hIST1 in cytokinesis."Mol. Biol. Cell 20:1374-1387(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis."Mol. Biol. Cell 23:4347-4361(2012) [PubMed] [Europe PMC] [Abstract]
  8. "ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes."Proc. Natl. Acad. Sci. U.S.A. 109:17424-17429(2012) [PubMed] [Europe PMC] [Abstract]