ADP Ribosylation Factor Like Protein 8A (ARL8A)

[Edit]

ARL10B; Gie2; ADP-ribosylation factor-like protein 10B; Novel small G protein indispensable for equal chromosome segregation 2

ADP Ribosylation Factor Like Protein 8A (ARL8A)
Arl8a and Arl8b , localise to lysosomes in mammalian cells, with the single homologue in Drosophila cells having a similar location. Conventionally, membrane binding of Arf and Arl proteins is mediated by both an N-terminal myristoyl group and an N-terminal amphipathic helix that is inserted into the lipid bilayer upon activation of the GTPase. Arl8a and Arl8b do not have N-terminal myristoylation sites, Arl8b is instead N-terminally acetylated, and an acetylated methionine is necessary for its lysosomal localization. Overexpression of Arl8a or Arl8b results in a microtubule-dependent redistribution of lysosomes towards the cell periphery. Live cell imaging shows that lysosomes move more frequently both toward and away from the cell periphery, suggesting a role for Arl8a and Arl8b as positive regulators of lysosomal transport.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor Like Protein 8A (ARL8A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor Like Protein 8A (ARL8A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor Like Protein 8A (ARL8A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor Like Protein 8A (ARL8A) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor Like Protein 8A (ARL8A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor Like Protein 8A (ARL8A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor Like Protein 8A (ARL8A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor Like Protein 8A (ARL8A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor Like Protein 8A (ARL8A) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor Like Protein 8A (ARL8A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor Like Protein 8A (ARL8A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor Like Protein 8A (ARL8A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor Like Protein 8A (ARL8A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor Like Protein 8A (ARL8A) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor Like Protein 8A (ARL8A) ELISA Kit Customized Service Offer
  1. "Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation."J. Cell Sci. 117:4705-4715(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility."J. Cell Sci. 119:1494-1503(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Integral and associated lysosomal membrane proteins."Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of human ADP-ribosylation factor-like 10B."Submitted (MAY-2005) to the PDB data bank