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Nuclear Assembly Factor 1 (NAF1)

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H/ACA ribonucleoprotein complex non-core subunit NAF1

Nuclear Assembly Factor 1 (NAF1)
CCC R353
HGNC 25126
MGI 2682306
PubMed 12220502
UniProt Q96HR8
The human telomerase ribonucleoprotein particle (RNP) shares with box H/ACA small Cajal body (sca)RNPs and small nucleolar (sno)RNPs the proteins dyskerin, hGar1, hNhp2, and hNop10. How dyskerin, hGar1, hNhp2, and hNop10 assemble with box H/ACA scaRNAs, snoRNAs, and the RNA component of telomerase (hTR) in vivo remains unknown. HeLa hNaf1 associates with dyskerin and hNop10 as well as box H/ACA scaRNAs, snoRNAs, and hTR. Reduction of hNaf1 steady-state levels by RNAi significantly lowers accumulation of these components of box H/ACA scaRNP, snoRNP, and telomerase. hNaf1 is found predominantly in numerous discrete foci in the nucleoplasm and fails to accumulate within Cajal bodies or nucleoli. Altogether, these results suggest that hNaf1 intervenes in early assembly steps of human box H/ACA RNPs, including telomerase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Assembly Factor 1 (NAF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Assembly Factor 1 (NAF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Assembly Factor 1 (NAF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Assembly Factor 1 (NAF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Assembly Factor 1 (NAF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Assembly Factor 1 (NAF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Assembly Factor 1 (NAF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Assembly Factor 1 (NAF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Assembly Factor 1 (NAF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Assembly Factor 1 (NAF1) ELISA Kit Customized Service Offer
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