Stromal Membrane Associated Protein 2 (SMAP2)

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SMAP1L; Stromal Membrane-Associated GTPase-Activating Protein 2; Small ArfGAP2; Stromal membrane-associated protein 1-like

Stromal Membrane Associated Protein 2 (SMAP2)
SMAP2 exhibits GAP activity and interacts with clathrin heavy chain (CHC). SMAP2 interacts with the clathrin assembly protein CALM. Unlike SMAP1, however, SMAP2 appears to be a regulator of Arf1 in vivo, because cells transfected with a GAP-negative SMAP2 mutant were resistant to brefeldin A. SMAP2 colocalized with the adaptor proteins for clathrin AP-1 and EpsinR on the early endosomes/trans-Golgi-network (TGN). Moreover, overexpression of SMAP2 delayed the accumulation of TGN38/46 molecule on the TGN. This suggests that SMAP2 functions in the retrograde, early endosome-to-TGN pathway in a clathrin- and AP-1-dependent manner. Thus, the SMAP gene family constitutes an important ArfGAP subfamily, with each SMAP member exerting both common and distinct functions in vesicle trafficking.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Stromal Membrane Associated Protein 2 (SMAP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Stromal Membrane Associated Protein 2 (SMAP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Stromal Membrane Associated Protein 2 (SMAP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Stromal Membrane Associated Protein 2 (SMAP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stromal Membrane Associated Protein 2 (SMAP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Stromal Membrane Associated Protein 2 (SMAP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Stromal Membrane Associated Protein 2 (SMAP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Stromal Membrane Associated Protein 2 (SMAP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Stromal Membrane Associated Protein 2 (SMAP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stromal Membrane Associated Protein 2 (SMAP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Stromal Membrane Associated Protein 2 (SMAP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Stromal Membrane Associated Protein 2 (SMAP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Stromal Membrane Associated Protein 2 (SMAP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Stromal Membrane Associated Protein 2 (SMAP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stromal Membrane Associated Protein 2 (SMAP2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structure of the GAP domain of SMAP1L (LOC64744) stromal membrane-associated protein 1-like."Submitted (OCT-2006) to the PDB data bank