Hepatocellular Carcinoma Associated Antigen 59 (HCA59)

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C9orf78

Hepatocellular Carcinoma Associated Antigen 59 (HCA59)
Autoantibodies are often detected in hepatocellular carcinoma (HCC), and these responses may represent recognition of tumor Ags that are associated with transformation events. Two other Ags (HCA519 and HCA90) were highly overexpressed in HCC and also expressed in cancer cell lines of lung, prostate, and pancreas, but not in the respective normal tissues. Four other Ags were identified to be expressed in particular types of cancer cell lines (HCA520 in an ovarian cancer cell line, HCA59 and HCA67 in a colon cancer cell line, HCA58 in colon and ovarian cancer cell lines), but not in the normal tissue counterpart(s). In addition, abundant expression of complement inactivation factors was found in HCC. These results indicate a broad range expression of autoantigens in HCC patients.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hepatocellular Carcinoma Associated Antigen 59 (HCA59) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hepatocellular Carcinoma Associated Antigen 59 (HCA59) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hepatocellular Carcinoma Associated Antigen 59 (HCA59) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hepatocellular Carcinoma Associated Antigen 59 (HCA59) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hepatocellular Carcinoma Associated Antigen 59 (HCA59) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hepatocellular Carcinoma Associated Antigen 59 (HCA59) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hepatocellular Carcinoma Associated Antigen 59 (HCA59) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hepatocellular Carcinoma Associated Antigen 59 (HCA59) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hepatocellular Carcinoma Associated Antigen 59 (HCA59) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hepatocellular Carcinoma Associated Antigen 59 (HCA59) ELISA Kit Customized Service Offer
  1. "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies."J. Immunol. 169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]