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DDB1 And CUL4 Associated Factor 8 (DCAF8)

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WDR42A; WD Repeat Domain 42A

DDB1 And CUL4 Associated Factor 8 (DCAF8)
CCC R310
HGNC 24891
MGI 91860
RGD 1308513
UniProt Q5TAQ9
DCAF8 encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene.
The homozygous loop-tail (Lp) mouse has a severe neural tube closure defect, analogous to the craniorachischisis phenotype seen in humans. Linkage analysis and physical mapping have previously localized the Lp locus to a region on mouse chromosome 1 defined by the markers D1Mit113-Tagln2. Twenty-two genes, one EST, and one pseudogene have been identified using a combination of EST database screening, exon amplification, and genomic sequence analysis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DDB1 And CUL4 Associated Factor 8 (DCAF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DDB1 And CUL4 Associated Factor 8 (DCAF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DDB1 And CUL4 Associated Factor 8 (DCAF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DDB1 And CUL4 Associated Factor 8 (DCAF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for DDB1 And CUL4 Associated Factor 8 (DCAF8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DDB1 And CUL4 Associated Factor 8 (DCAF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DDB1 And CUL4 Associated Factor 8 (DCAF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DDB1 And CUL4 Associated Factor 8 (DCAF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DDB1 And CUL4 Associated Factor 8 (DCAF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for DDB1 And CUL4 Associated Factor 8 (DCAF8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DDB1 And CUL4 Associated Factor 8 (DCAF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DDB1 And CUL4 Associated Factor 8 (DCAF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DDB1 And CUL4 Associated Factor 8 (DCAF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DDB1 And CUL4 Associated Factor 8 (DCAF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for DDB1 And CUL4 Associated Factor 8 (DCAF8) ELISA Kit Customized Service Offer
  1. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1."Mol. Cell 23:709-721(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery."Nature 443:590-593(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A)."FEBS Lett. 586:1079-1085(2012) [PubMed] [Europe PMC] [Abstract]
  11. "A Y2H-seq approach defines the human protein methyltransferase interactome."Nat. Methods 10:339-342(2013) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Ubiquitin ligase defect by DCAF8 mutation causes HMSN2 with giant axons."Neurology 82:873-878(2014) [PubMed] [Europe PMC] [Abstract]