Pentatricopeptide Repeat Domain Protein 3 (PTCD3)

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MRPS39; TRG15; Transformation-related gene 15 protein; 28S ribosomal protein S39, mitochondrial

Pentatricopeptide Repeat Domain Protein 3 (PTCD3)
The basic components and mechanisms of mitochondrial transcription in mammals have been described, however, the components involved in mRNA processing, translation and stability remain largely unknown. In plants, pentatricopeptide domain RNA-binding proteins regulate the stability, expression and translation of mitochondrial transcripts. PTCD3 is a mitochondrial protein that associates with the small subunit of mitochondrial ribosomes. PTCD3 knockdown and over expression did not affect mitochondrial mRNA levels, suggesting that PTCD3 is not involved in RNA processing and stability. However, lowering PTCD3 in 143B osteosarcoma cells decreased mitochondrial protein synthesis, mitochondrial respiration and the activity of Complexes III and IV, suggesting that PTCD3 has a role in mitochondrial translation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pentatricopeptide Repeat Domain Protein 3 (PTCD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pentatricopeptide Repeat Domain Protein 3 (PTCD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pentatricopeptide Repeat Domain Protein 3 (PTCD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pentatricopeptide Repeat Domain Protein 3 (PTCD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pentatricopeptide Repeat Domain Protein 3 (PTCD3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pentatricopeptide Repeat Domain Protein 3 (PTCD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pentatricopeptide Repeat Domain Protein 3 (PTCD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pentatricopeptide Repeat Domain Protein 3 (PTCD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pentatricopeptide Repeat Domain Protein 3 (PTCD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pentatricopeptide Repeat Domain Protein 3 (PTCD3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pentatricopeptide Repeat Domain Protein 3 (PTCD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pentatricopeptide Repeat Domain Protein 3 (PTCD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pentatricopeptide Repeat Domain Protein 3 (PTCD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pentatricopeptide Repeat Domain Protein 3 (PTCD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pentatricopeptide Repeat Domain Protein 3 (PTCD3) ELISA Kit Customized Service Offer
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  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Pentatricopeptide repeat domain protein 3 associates with the mitochondrial small ribosomal subunit and regulates translation."FEBS Lett. 583:1853-1858(2009) [PubMed] [Europe PMC] [Abstract]
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