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Fas Associated Factor 2 (FAF2)

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UBXD8; ETEA; UBXN3B; UBX Domain Containing 8; Expressed In T Cells And Eosinophils In Atopic Dermatitis; UBX Domain Protein 3B

Fas Associated Factor 2 (FAF2)
CCC R277
HGNC 24666
MGI 1923827
RGD 1306577
UniProt Q96CS3
FAF2 is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients.
Eosinophils from AD patients expressed ETEA at a significantly higher level than the healthy controls. The overall sequence of the 445 aa deduced polypeptide from the cloned ETEA cDNA showed homology to human Fas-associated factor 1 (FAF1), which is involved in Fas-mediated apoptosis. However, the interaction of ETEA with the Fas death domain was weaker than that of FAF1, as studied in yeast two-hybrid experiments. The ETEA-EGFP fusion protein was expressed in cytoplasm. The enhanced expression of ETEA may play a role in the regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fas Associated Factor 2 (FAF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fas Associated Factor 2 (FAF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fas Associated Factor 2 (FAF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fas Associated Factor 2 (FAF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fas Associated Factor 2 (FAF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fas Associated Factor 2 (FAF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fas Associated Factor 2 (FAF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fas Associated Factor 2 (FAF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fas Associated Factor 2 (FAF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fas Associated Factor 2 (FAF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fas Associated Factor 2 (FAF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fas Associated Factor 2 (FAF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fas Associated Factor 2 (FAF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fas Associated Factor 2 (FAF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fas Associated Factor 2 (FAF2) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients."Biochem. Biophys. Res. Commun. 297:1282-1290(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  4. "SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins."Proc. Natl. Acad. Sci. U.S.A. 105:12325-12330(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets."J. Cell Sci. 122:3694-3702(2009) [PubMed] [Europe PMC] [Abstract]
  7. "The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER."Mol. Cell 36:28-38(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of the novel identified UBA-like domain in the N-terminal of human ETEA protein."Submitted (JUN-2006) to the PDB data bank