≡

Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1)

[Edit]

Eps15R; Eps15-related protein

Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1)
CCC R272
HGNC 24634
MGI 104582
PubMed 21738480
RGD 1565708
UniProt Q9UBC2
Wiki EPS15L1
EPS15L1 interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2). Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis.
Congenital limb malformations are the second most common birth defects observed in infants. Split hand foot malformation (SHFM), also known as central ray deficiency, ectrodactyly and cleft hand/foot, occurs isolated or in combination with other malformations. The deletion is 0.99 Mb in size and contains 28 genes. The proximal breakpoint of the deletion is in EPS15L1, which may be involved in vertebrate limb development.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epidermal Growth Factor Receptor Pathway Substrate 15 Like Protein 1 (EPS15L1) ELISA Kit Customized Service Offer
  1. "Selection system for genes encoding nuclear-targeted proteins."Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "eps15 and eps15R are essential components of the endocytic pathway."Cancer Res. 57:5498-5504(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "FCHo proteins are nucleators of clathrin-mediated endocytosis."Science 328:1281-1284(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis."Mol. Biol. Cell 23:2905-2916(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."Nat. Cell Biol. 14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]