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DDB1 And CUL4 Associated Factor 13 (DCAF13)

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WDSOF1; Gm83; WD Repeats And SOF1 Domain Containing

DDB1 And CUL4 Associated Factor 13 (DCAF13)
CCC R255
HGNC 24535
MGI 2684929
RGD 1308458
UniProt Q9NV06
DCAF13 belongs to the WD repeat DCAF13/WDSOF1 family.Possible role in ribosomal RNA processing By similarity. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
The analysis of linkage disequilibrium (LD) in the WDSOF1 gene revealed that rs1370005 and 3 other non-synonymous SNPs (Arg47Ser, Pro108Leu and Ile194Val) lie in a 30-kb region of high LD. WDSOF1 mRNA was expressed in mouse primary osteoblasts and osteoclasts, suggesting that WDSOF1 plays some roles in the bone metabolism. A trend test showed that Arg47Ser, Pro108Leu, and Ile194Val genotypes were significant associated with total body BMD. These non-synonymous WDSOF1 polymorphisms play a role in the genetic susceptibility to osteoporosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DDB1 And CUL4 Associated Factor 13 (DCAF13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DDB1 And CUL4 Associated Factor 13 (DCAF13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DDB1 And CUL4 Associated Factor 13 (DCAF13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DDB1 And CUL4 Associated Factor 13 (DCAF13) CLIA Kit Customized Service Offer
n/a ELISA Kit for DDB1 And CUL4 Associated Factor 13 (DCAF13) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DDB1 And CUL4 Associated Factor 13 (DCAF13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DDB1 And CUL4 Associated Factor 13 (DCAF13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DDB1 And CUL4 Associated Factor 13 (DCAF13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DDB1 And CUL4 Associated Factor 13 (DCAF13) CLIA Kit Customized Service Offer
n/a ELISA Kit for DDB1 And CUL4 Associated Factor 13 (DCAF13) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DDB1 And CUL4 Associated Factor 13 (DCAF13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DDB1 And CUL4 Associated Factor 13 (DCAF13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DDB1 And CUL4 Associated Factor 13 (DCAF13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DDB1 And CUL4 Associated Factor 13 (DCAF13) CLIA Kit Customized Service Offer
n/a ELISA Kit for DDB1 And CUL4 Associated Factor 13 (DCAF13) ELISA Kit Customized Service Offer
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  4. "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1."Mol. Cell 23:709-721(2006) [PubMed] [Europe PMC] [Abstract]
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  7. "Dynamics of WD-repeat containing proteins in SSU processome components."Biochem. Cell Biol. 92:191-199(2014) [PubMed] [Europe PMC] [Abstract]