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COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8)

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CSN8; SGN8; JAB1-containing signalosome subunit 8

COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8)
CCC R225
HGNC 24335
MGI 1915363
PubMed 22992343
RGD 1311404
UniProt Q99627
Wiki COPS8
COPS8 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) CLIA Kit Customized Service Offer
n/a ELISA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) CLIA Kit Customized Service Offer
n/a ELISA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) CLIA Kit Customized Service Offer
n/a ELISA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 8 (COPS8) ELISA Kit Customized Service Offer
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