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Nuclear Import 7 Homolog (NIP7)

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CGI-37; KD93; 60S Ribosome Subunit Biogenesis Protein

Nuclear Import 7 Homolog (NIP7)
CCC R224
HGNC 24328
MGI 1913414
PubMed 20798176
RGD 620069
UniProt Q9Y221
Wiki NIP7
Eukaryotic ribosome biogenesis requires the function of a large number of trans-acting factors which interact transiently with the nascent pre-rRNA and dissociate as the ribosomal subunits proceed to maturation and export to the cytoplasm. Loss-of-function mutations in human trans-acting factors or ribosome components may lead to genetic syndromes.
The NIP7 protein is restricted to the nuclear compartment and co-sediments with complexes with molecular masses in the range of 40S-80S, suggesting an association to nucleolar pre-ribosomal particles. Downregulation of NIP7 affects cell proliferation, consistently with an important role for NIP7 in rRNA biosynthesis in human cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Import 7 Homolog (NIP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Import 7 Homolog (NIP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Import 7 Homolog (NIP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Import 7 Homolog (NIP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Import 7 Homolog (NIP7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Import 7 Homolog (NIP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Import 7 Homolog (NIP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Import 7 Homolog (NIP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Import 7 Homolog (NIP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Import 7 Homolog (NIP7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Import 7 Homolog (NIP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Import 7 Homolog (NIP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Import 7 Homolog (NIP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Import 7 Homolog (NIP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Import 7 Homolog (NIP7) ELISA Kit Customized Service Offer
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  6. "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D."J. Biol. Chem. 279:8343-8350(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The Shwachman-Bodian-Diamond syndrome associated protein interacts with HsNip7 and its down-regulation affects gene expression at the transcriptional and translational levels."Exp. Cell Res. 313:4180-4195(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing."PLoS ONE 6:E29174-E29174(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of KD93, a novel protein expressed in human hematopoietic stem/progenitor cells."J. Struct. Biol. 148:370-374(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of Northeast structural genomics consortium target HR2118: a human homolog of Saccharomyces cerevisiae NIP7p."Submitted (JUN-2004) to the PDB data bank
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]