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RasGEF Domain Family, Member 1A (RASGEF1A)

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RasGEF Domain Family, Member 1A (RASGEF1A)
CCC R203
HGNC 24246
MGI 1917977
PubMed 19645719
RGD 1305836
UniProt Q8N9B8
RASGEF1A encodes a putative Ras guanine nucleotide exchange factor domain-containing protein. RASGEF1A protein has a guanine nucleotide exchange activity to K-RAS, H-RAS, and N-RAS proteins in vitro. Consistently, exogenous RASGEF1A expression increased the activity of Ras. In addition, suppression of RASGEF1A by small interfering RNA retarded the growth of cholangiocarcinoma cells. Interestingly, COS7 cells expressing exogenous RASGEF1A showed enhanced cellular motility in Transwell and wound-healing assays.
RASGEF1A may play an essential role for proliferation and progression of ICC.RASGEF1A may be a promising therapeutic target for the majority of ICCs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RasGEF Domain Family, Member 1A (RASGEF1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RasGEF Domain Family, Member 1A (RASGEF1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RasGEF Domain Family, Member 1A (RASGEF1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RasGEF Domain Family, Member 1A (RASGEF1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RasGEF Domain Family, Member 1A (RASGEF1A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RasGEF Domain Family, Member 1A (RASGEF1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RasGEF Domain Family, Member 1A (RASGEF1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RasGEF Domain Family, Member 1A (RASGEF1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RasGEF Domain Family, Member 1A (RASGEF1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RasGEF Domain Family, Member 1A (RASGEF1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RasGEF Domain Family, Member 1A (RASGEF1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RasGEF Domain Family, Member 1A (RASGEF1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RasGEF Domain Family, Member 1A (RASGEF1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RasGEF Domain Family, Member 1A (RASGEF1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RasGEF Domain Family, Member 1A (RASGEF1A) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma."Clin. Cancer Res. 12:6611-6616(2006) [PubMed] [Europe PMC] [Abstract]
  4. "RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange."FEBS J. 276:4607-4616(2009) [PubMed] [Europe PMC] [Abstract]