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LETM1 Domain Containing Protein 1 (LETMD1)

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HCCR1; HCRR-2; Cervical Cancer 1 Protooncogene; Cervical cancer proto-oncogene 2 protein

LETM1 Domain Containing Protein 1 (LETMD1)
CCC R202
HGNC 24241
MGI 1915864
PubMed 20196787
RGD 1596738
UniProt Q6P1Q0
Wiki LETMD1
LETMD1 is involved in tumorigenesis and may function as a negative regulator of the TP53/p53. It is found in kidney, liver, skeletal muscle, heart and brain and is over-expressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix. There are six isoforms.
HCCR-2 that was overexpressed in various human tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon, and uterine cervix. Ectopic expression of HCCR-2 resulted in direct tumorigenic conversions of NIH/3T3 and Rat1 fibroblasts. HCCR-2 probably represents a new oncogene that is related to tumorigenesis, functioning as a negative regulator of the p53 tumor suppressor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR202Hu01 Recombinant LETM1 Domain Containing Protein 1 (LETMD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR202Hu21 Monoclonal Antibody to LETM1 Domain Containing Protein 1 (LETMD1) WB; IHC; ICC; IP.
PAR202Hu01 Polyclonal Antibody to LETM1 Domain Containing Protein 1 (LETMD1) WB; IHC; ICC; IP.
Assay Kits SER202Hu ELISA Kit for LETM1 Domain Containing Protein 1 (LETMD1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LETM1 Domain Containing Protein 1 (LETMD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LETM1 Domain Containing Protein 1 (LETMD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LETM1 Domain Containing Protein 1 (LETMD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LETM1 Domain Containing Protein 1 (LETMD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LETM1 Domain Containing Protein 1 (LETMD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LETM1 Domain Containing Protein 1 (LETMD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LETM1 Domain Containing Protein 1 (LETMD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LETM1 Domain Containing Protein 1 (LETMD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LETM1 Domain Containing Protein 1 (LETMD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LETM1 Domain Containing Protein 1 (LETMD1) ELISA Kit Customized Service Offer
  1. "Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization."Oncogene 22:4679-4689(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis."BMC Cell Biol. 8:50-50(2007) [PubMed] [Europe PMC] [Abstract]
  7. "HCCRBP-1 directly interacting with HCCR-1 induces tumorigenesis through P53 stabilization."Int. J. Cancer 122:501-508(2008) [PubMed] [Europe PMC] [Abstract]