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Ankyrin Repeat Domain Protein 30B (ANKRD30B)

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NY-BR-1.1; Serologically defined breast cancer antigen NY-BR-1.1

Ankyrin Repeat Domain Protein 30B (ANKRD30B)
CCC R186
HGNC 24165
UniProt Q9BXX2
NY-BR-1, representing 6 of 14 clones isolated, showed tissue-restricted mRNA expression in breast and testis but not in 13 other normal tissues tested. Additional structural features include five tandem ankyrin repeats, implying a role for NY-BR-1 in protein-protein interactions. NY-BR-1 thus represents a breast tissue-specific putative transcription factor with autoimmunogenicity in breast cancer patients. In addition to NY-BR-1, a homologous gene, NY-BR-1.1, was identified in this study. NY-BR-1.1 shares 54% amino acid homology with NY-BR-1 and also shows tissue-restricted mRNA expression. However, unlike NY-BR-1, NY-BR-1.1 mRNA is expressed in brain, in addition to breast and testis. The exon structure of NY-BR-1.1 remains to be defined. Using human genome database, NY-BR-1 was localized to chromosome 10p11-p12, and NY-BR-1.1 was tentatively localized to chromosome 9.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat Domain Protein 30B (ANKRD30B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat Domain Protein 30B (ANKRD30B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat Domain Protein 30B (ANKRD30B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat Domain Protein 30B (ANKRD30B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat Domain Protein 30B (ANKRD30B) ELISA Kit Customized Service Offer
  1. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
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  3. "Identification of a tissue-specific putative transcription factor in breast tissue by serological screening of a breast cancer library."Cancer Res. 61:2055-2061(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]