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Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d)

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PP2A Subunit B Isoform Delta; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d)
CCC R140
HGNC 23732
MGI 1289252
PubMed 22539979
RGD 708356
UniProt Q66LE6
PP2A is a multimeric serine/threonine protein phosphatase consisting of a 36 kDa catalytic subunit (PP2AC) and a 65 kDa scaffolding subunit. PPP2R2A and have distinct and opposing roles in the regulation of TGF-β/Activin/Nodal signalling. Smad2 association with the homeodomain transcription factor goosecoid, the C2-WW-HECT ubiquitin ligase, WWP2, and the protein phosphatase 2 regulatory subunit, PPP2R2D, as well as interactions between Smad4 and either Map kinase kinase 3 (MAP2K3) or TC21 (RRAS2). The identification of WWP2, extends the range of C2-WW-HECT ubiquitin ligases that function in Smad signaling beyond the Smurf subfamily and the presence of PPP2R2D suggests one potential mechanism for turning off Smad signaling by dephosphorylation. Overexpressed PPP2R2D was found to inhibit TGFβ-dependent Smad signaling .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2, Regulatory Subunit B Delta (PPP2R2d) ELISA Kit Customized Service Offer
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  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]