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MORC Family CW-Type Zinc Finger Protein 2 (MORC2)

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ZCWCC1; ZCW3; Zinc Finger, CW-Type With Coiled-Coil Domain 1; Zinc Finger, CW Type With Coiled-Coil Domain 1

MORC Family CW-Type Zinc Finger Protein 2 (MORC2)
CCC R119
HGNC 23573
MGI 1921772
PubMed 14607086
RGD 1310842
UniProt Q9Y6X9
Wiki MORC2
MORC2 is a member of the MORC protein family. The MORC proteins contain a CW-type zinc finger domain and are predicted to have the function of regulating transcription, but no MORC2 target genes have been identified. The protected region 4 (PR4) was important for the repression function of MORC2. Moreover, MORC2 decreased the acetylation level of histone H3 at the CAIX promoter. Meanwhile, trichostatin A (TSA) had an increasing effect on CAIX promoter activity. Among the six HDACs tested, histone deacetylase 4 (HDAC4) had a much more prominent effect on CAIX repression. ChIP and ChIP Re-IP assays showed that MORC2 and HDAC4 were assembled on the same region of the CAIX promoter. Both proteins are simultaneously present in the PR4-binding complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MORC Family CW-Type Zinc Finger Protein 2 (MORC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MORC Family CW-Type Zinc Finger Protein 2 (MORC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MORC Family CW-Type Zinc Finger Protein 2 (MORC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MORC Family CW-Type Zinc Finger Protein 2 (MORC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MORC Family CW-Type Zinc Finger Protein 2 (MORC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MORC Family CW-Type Zinc Finger Protein 2 (MORC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MORC Family CW-Type Zinc Finger Protein 2 (MORC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MORC Family CW-Type Zinc Finger Protein 2 (MORC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MORC Family CW-Type Zinc Finger Protein 2 (MORC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MORC Family CW-Type Zinc Finger Protein 2 (MORC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MORC Family CW-Type Zinc Finger Protein 2 (MORC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MORC Family CW-Type Zinc Finger Protein 2 (MORC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MORC Family CW-Type Zinc Finger Protein 2 (MORC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MORC Family CW-Type Zinc Finger Protein 2 (MORC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MORC Family CW-Type Zinc Finger Protein 2 (MORC2) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Identification and expression analysis of a novel CW-type zinc finger protein MORC2 in cancer cells."Anat. Rec. 293:1002-1009(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX."Nucleic Acids Res. 38:2813-2824(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Cytosolic functions of MORC2 in lipogenesis and adipogenesis."Biochim. Biophys. Acta 1843:316-326(2014) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]