≡

Calcium Homeostasis Modulator 3 (CALHM3)

[Edit]

FAM26A; Family With Sequence Similarity 26, Member A

Calcium Homeostasis Modulator 3 (CALHM3)
CCC R105
HGNC 23458
MGI 3645665
PubMed 19997627
RGD 1560215
UniProt Q86XJ0
CALHM3 belongs to the FAM26 family. SNPs in the genes of two other CALHM subtypes, CALHM2 and CALHM3, were also studied.
Alzheimer's disease (AD) is a genetically heterogeneous disorder characterized by early hippocampal atrophy and cerebral amyloid-beta (Abeta) peptide deposition. CALHM1 homomultimerizes, shares strong sequence similarities with the selectivity filter of the NMDA receptor, and generates a large Ca(2+) conductance across the plasma membrane. CALHM1 P86L polymorphism is significantly associated with AD in independent case-control studies of 3404 participants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Homeostasis Modulator 3 (CALHM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Homeostasis Modulator 3 (CALHM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Homeostasis Modulator 3 (CALHM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Homeostasis Modulator 3 (CALHM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Homeostasis Modulator 3 (CALHM3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Homeostasis Modulator 3 (CALHM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Homeostasis Modulator 3 (CALHM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Homeostasis Modulator 3 (CALHM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Homeostasis Modulator 3 (CALHM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Homeostasis Modulator 3 (CALHM3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Homeostasis Modulator 3 (CALHM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Homeostasis Modulator 3 (CALHM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Homeostasis Modulator 3 (CALHM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Homeostasis Modulator 3 (CALHM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Homeostasis Modulator 3 (CALHM3) ELISA Kit Customized Service Offer
  1. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk." Cell 133:1149-1161(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations."PLoS ONE 4:E7682-E7682(2009) [PubMed] [Europe PMC] [Abstract]