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Family With Sequence Similarity 21, Member C (FAM21C)

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VPEF; Vaccinia Virus Penetration Factor; WASH complex subunit FAM21C

Family With Sequence Similarity 21, Member C (FAM21C)
CCC R096
HGNC 23414
MGI 106463
PubMed 14702039
RGD 735230
UniProt Q9Y4E1
Wiki FAM21C
VPEF, is conserved in mouse, human, and Chinese hamster. Immunofluorescence and electron microscopy showed that fluorescence-tagged or endogenous VPEF associated with plasma membrane lipid rafts and intracellular vesicles in HeLa cells.The deduced protein contains 1,353 amino acids. RT-PCR detected robust FAM21C expression in all tissues examined.IMV transiently associate with FAM21C during virus entry in a postattachment penetration step. Small interfering RNA targeting VPEF reduced virus penetration. VPEF also participated in intracellular transport of dextran, which undergoes fluid-phase endocytosis, but not transferrin (TF), which undergoes clathrin-mediated endocytosis. VPEF partly colocalized with RAB11A, a recycling endosome marker.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 21, Member C (FAM21C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 21, Member C (FAM21C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 21, Member C (FAM21C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 21, Member C (FAM21C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 21, Member C (FAM21C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 21, Member C (FAM21C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 21, Member C (FAM21C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 21, Member C (FAM21C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 21, Member C (FAM21C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 21, Member C (FAM21C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 21, Member C (FAM21C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 21, Member C (FAM21C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 21, Member C (FAM21C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 21, Member C (FAM21C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 21, Member C (FAM21C) ELISA Kit Customized Service Offer
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  6. "A novel cellular protein, VPEF, facilitates vaccinia virus penetration into HeLa cells through fluid phase endocytosis."J. Virol. 82:7988-7999(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A FAM21-containing WASH complex regulates retromer-dependent sorting."Dev. Cell 17:699-711(2009) [PubMed] [Europe PMC] [Abstract]
  9. "The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex."Dev. Cell 17:712-723(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes."Proc. Natl. Acad. Sci. U.S.A. 107:10442-10447(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35."Biochem. J. 442:209-220(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer."Mol. Biol. Cell 23:2352-2361(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer."Biol. Cell 105:191-207(2013) [PubMed] [Europe PMC] [Abstract]
  18. "Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation."Curr. Biol. 24:1670-1676(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling."J. Cell Sci. 127:4940-4953(2014) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A." Mol. Biol. Cell 26:91-103(2015) [PubMed] [Europe PMC] [Abstract]