Annexin A8 Like Protein 2 (ANXA8L2)

ANXA8L2 encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.

Annexin is a common name for a group of cellular proteins. They are found in all kingdoms (animal, plant and fungi) with the exception of the bacteria. Annexin is also known as lipocortin. Lipocortins suppress phospholipase A2. This is the mechanism by which glucocorticoids (primarily cortisol) inhibits inflammation.