Tetraspanin 14 (TSPAN14)

TSPAN14 belongs to the tetraspanin (TM4SF) family. Tetraspanins are a family of membrane proteins found in all multicellular eukaryotes.

Tetraspanins, also called tetraspans or the transmembrane 4 superfamily (TM4SF), have four transmembrane domains, intracellular N and C-termini and two extracellular domains, one short (small extracellular domain or loop (SED/SEL or EC1) and one longer, typically 100 amino acid residues (large extracellular domain/loop (LED/LEL or EC2). Although several protein families have four transmembrane domains, tetraspanins are defined by conserved domains listed under pfam00335.12 . The key features are four or more cysteine residues in the EC2 domain, with two in a highly conserved 'CCG' motif.