DHRS4 Antisense Gene Protein 1 (DHRS4-AS1)

C14orf167 is a typical naturally occurring antisense gene to DHRS4. These two genes have overlapped promoters and 5' 1332 bp coding regions that belongs to the cis head-to-head bidirectional transcription. Given such a positional relationship in the 5' sequence, DHRS4 and C14orf167 will interfere with each other in transcription initiation.

Due to the homologies within the DHRS4 gene cluster, the transcripts of C14orf167 match with exon 1 in the primary transcripts of DHRS4L2 or DHRS4L1, and possibly take part in the splicing out of exon 1 from the transcripts initiated from exon a1/a2. The sequence at the 5'end of DHRS4L2 exon 1 is consistent with the submodel splice acceptor AC, instead of the typical AG sequence.