≡

Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15)

[Edit]

MTH2; Nudix Type Motif 15; Probable 8-oxo-dGTP diphosphatase NUDT15; 7,8-dihydro-8-oxoguanine-triphosphatase NUDT15

Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15)
CCC R057
HGNC 23063
MGI 2443366
RGD 1308292
UniProt Q9NV35
MutT-related proteins degrade 8-oxo-7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP), a mutagenic substrate for DNA synthesis, in the nucleotide pool, thereby preventing DNA replication errors. A new member of MutT-related protein, MTH2, which possesses the 23-amino acid MutT module. The cloned mouse MTH2 (mMTH2) cDNA was expressed in Escherichia coli mutT(-) cells and the protein was purified. mMTH2 protein hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, with Km of 32 microM. Expression of cDNA for mMTH2 reduced significantly the elevated level of spontaneous mutation frequency of E. coli mutT(-) cells. Thus, MTH2 has a potential to protect the genetic material from the untoward effects of endogenous oxygen radicals. MTH2 could act as an MTH1 redundancy factor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 15 (NUDT15) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2."J. Biol. Chem. 284:19310-19320(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2."J. Biol. Chem. 287:21541-21549(2012) [PubMed] [Europe PMC] [Abstract]