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Connector Enhancer Of Kinase Suppressor Of Ras 3 (CNKSR3)

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MAGI1; CNK3; Membrane Associated Guanylate Kinase Interacting Protein-Like 1; CNK homolog protein 3; CNKSR family member 3; Maguin-like protein

Connector Enhancer Of Kinase Suppressor Of Ras 3 (CNKSR3)
CCC R056
HGNC 23034
MGI 2674130
PubMed 19567370
RGD 1307544
UniProt Q6P9H4
CNKSR3 was highly expressed in the renal cortical collecting duct (CCD), the prime target segment of aldosterone-regulated sodium retention in the kidney. CCD cell lines stably overexpressing or silencing CNKSR3 were electrophysiologically analyzed and show that CNKSR3 expression correlated with and is required for ENaC-mediated transepithelial sodium transport. In parallel, CNKSR3 expression led to decreased MEK phosphorylation.
CNKSR3, a homologue of scaffold proteins involved in MAPK pathway regulation, is a direct target of MR and is required for the maintenance of transepithelial sodium transport in the kidney. Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Connector Enhancer Of Kinase Suppressor Of Ras 3 (CNKSR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Connector Enhancer Of Kinase Suppressor Of Ras 3 (CNKSR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Connector Enhancer Of Kinase Suppressor Of Ras 3 (CNKSR3) Polyclonal Antibody Customized Service Offer
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Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Connector Enhancer Of Kinase Suppressor Of Ras 3 (CNKSR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Connector Enhancer Of Kinase Suppressor Of Ras 3 (CNKSR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Connector Enhancer Of Kinase Suppressor Of Ras 3 (CNKSR3) Polyclonal Antibody Customized Service Offer
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  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel."FASEB J. 23:3936-3946(2009) [PubMed] [Europe PMC] [Abstract]