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Solute Carrier Family 16, Member 11 (SLC16A11)

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MCT11; Monocarboxylate Transporter 11

Solute Carrier Family 16, Member 11 (SLC16A11)
CCC R041
HGNC 23093
MGI 2663709
UniProt Q8NCK7
SLC16A11, is a 471 proton-linked monocarboxylate transporter that catalyzes the rapid transport of monocarboxylates across the plasma membrane. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. Proteins belonging to the MCT family contain between 10-12 transmembranehelical domains, with the amino and carboxy-termini located in the cytoplasm.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 16, Member 11 (SLC16A11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 16, Member 11 (SLC16A11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 16, Member 11 (SLC16A11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 16, Member 11 (SLC16A11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 16, Member 11 (SLC16A11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 16, Member 11 (SLC16A11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 16, Member 11 (SLC16A11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 16, Member 11 (SLC16A11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 16, Member 11 (SLC16A11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 16, Member 11 (SLC16A11) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico."Nature 506:97-101(2014) [PubMed] [Europe PMC] [Abstract]