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H2A Histone Family, Member B1 (H2AFB1)

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H2A Barr body-deficient; Histone H2A-Bbd type 1

H2A Histone Family, Member B1 (H2AFB1)
CCC R038
HGNC 22516
MGI 1915481
PubMed 11266453
UniProt P0C5Y9
Wiki H2AFB1
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family.
H2AFB1 is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most centromeric copy which is in intron 22 of the F8 gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant H2A Histone Family, Member B1 (H2AFB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to H2A Histone Family, Member B1 (H2AFB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to H2A Histone Family, Member B1 (H2AFB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for H2A Histone Family, Member B1 (H2AFB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for H2A Histone Family, Member B1 (H2AFB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant H2A Histone Family, Member B1 (H2AFB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to H2A Histone Family, Member B1 (H2AFB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to H2A Histone Family, Member B1 (H2AFB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for H2A Histone Family, Member B1 (H2AFB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for H2A Histone Family, Member B1 (H2AFB1) ELISA Kit Customized Service Offer
  1. "Investigation of the factor VIII intron 22 repeated region (int22h) and the associated inversion junctions."Hum. Mol. Genet. 4:1217-1224(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA."EMBO J. 23:3314-3324(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I."Mol. Cell. Biol. 25:10639-10651(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Dissection of the unusual structural and functional properties of the variant H2A.Bbd nucleosome."EMBO J. 25:4234-4244(2006) [PubMed] [Europe PMC] [Abstract]
  7. "ATP-dependent chromatin remodeling is required for base excision repair in conventional but not in variant H2A.Bbd nucleosomes."Mol. Cell. Biol. 27:5949-5956(2007) [PubMed] [Europe PMC] [Abstract]
  8. "H2A.Bbd: a quickly evolving hypervariable mammalian histone that destabilizes nucleosomes in an acetylation-independent way."FASEB J. 22:316-326(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quickly evolving histones, nucleosome stability and chromatin folding: all about histone H2A.Bbd."Gene 413:1-7(2008) [PubMed] [Europe PMC] [Abstract]
  10. "H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis."Nucleic Acids Res. 38:1780-1789(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells."Mol. Cell 47:596-607(2012) [PubMed] [Europe PMC] [Abstract]