≡

Family With Sequence Similarity 5, Member C (FAM5C)

[Edit]

DBCCR1L; DBCCR1L1; DBCCR1-like protein 1; BMP/retinoic acid-inducible neural-specific protein 3

Family With Sequence Similarity 5, Member C (FAM5C)
CCC R030
HGNC 22393
MGI 2443035
PubMed 22377736
RGD 708421
UniProt Q76B58
FAM5C contributes to aggressive periodontitis. Polymorphisms were identified within the FAM5C that show genetic linkage to and are associated with myocardial infarction (MI) in GENECARD. The association was confirmed in an independent CAD case-control sample and strong association with MI was identified with single nucleotide polymorphisms in the 3' end of FAM5C. FAM5C genotypes were also correlated with expression of the gene in human aorta. Expression levels of FAM5C decreased with increasing passage of proliferating aortic smooth muscle cells (SMC) suggesting a role for this molecule in smooth muscle cell proliferation and senescence.These data implicate FAM5C alleles in the risk of myocardial infarction and suggest further functional studies of FAM5C are required to identify the gene's contribution to atherosclerosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR030Hu01 Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAR030Hu01 Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
MAR030Hu21 Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
Assay Kits SER030Hu ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Bone morphogenetic protein and retinoic acid-inducible neural specific protein-3 is expressed in gonadotrope cell pituitary adenomas and induces proliferation, migration, and invasion."Endocrinology 148:967-975(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Genetic and functional association of FAM5C with myocardial infarction."BMC Med. Genet. 9:33-33(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Expression of the FAM5C in tongue squamous cell carcinoma."Oncol. Rep. 22:1005-1011(2009) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]