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Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1)

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Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1)
CCC R021
HGNC 22214
MGI 1917631
PubMed 21575909
RGD 1306873
UniProt Q7Z6L1
A previously uncharacterized tectonin b-propeller repeat protein, , associated reciprocally with ATG12, ATG3 and ATG5, indicating its involvement in the ATG8 lipidation pathway. The WD40-repeat protein ATG16L1 and TECPR1 also associated with theCCT chaperonin complex implicated in the folding of WD40 proteins10. TECPR1 also associated with FLJ12716, TTC15 and components of the TRAPP vesicle-tethering complex, includingTRS85, as well as TRAPPC2L,TRAPPC3, TRAPPC4 and TRAPPC5 with subthreshold WDN-scores. In contrast, depletion of TECPR1 and its associated protein TTC15 led to an increase in autophagosome number. Interestingly, depletion of TTC15 also resulted in a defect in flux, whereas depletion of TECPR1 did not, indicating that these proteins act at distinct steps in the process.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tectonin Beta Propeller Repeat Containing Protein 1 (TECPR1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens."Cell Host Microbe 9:376-389(2011) [PubMed] [Europe PMC] [Abstract]
  9. "A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate."Mol. Cell 45:629-641(2012) [PubMed] [Europe PMC] [Abstract]