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Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3)

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MIC19; MINOS3; MICOS complex subunit MIC19

Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3)
CCC R004
HGNC 21906
MGI 1913325
PubMed 21081504
RGD 1310325
UniProt Q9NX63
ChChd3 contains a myristylation motif followed by DUF domain and a CHCH domain. In mouse fibroblasts, the endogenous ChChd3 is primarily localized to mitochondria, sometimes also seen in nucleus. However, over-expressed ChChd3 is localized only to mitochondria. Deletion of CHCH domain disrupts mitochondrial localization suggesting that CHCH domain is an essential targeting motif in ChChd3. In vitro protein import studies showed that in addition to cysteines in CHCH domain, myristoylation is also necessary for targeting the protein to the IM of mitochondria. Over-expressed ChChd3 in HEK 293 cells binds to PKA and shows a clear increase in phosphorylation at Thr10 upon stimulation with 8-CPT cAMP.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 3 (CHCHD3) ELISA Kit Customized Service Offer
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  11. "MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization."Mol. Biol. Cell 23:247-257(2012) [PubMed] [Europe PMC] [Abstract]
  12. "CHCM1/CHCHD6, a novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology."J. Biol. Chem. 287:7411-7426(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Cloning and functional analysis of FLJ20420: a novel transcription factor for the BAG-1 promoter."PLoS ONE 7:E34832-E34832(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Uniform nomenclature for the mitochondrial contact site and cristae organizing system." J. Cell Biol. 204:1083-1086(2014) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]