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Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1)

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ORCA; CENP33; Centromere protein 33; Origin Recognition Complex Associated

Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1)
CCC Q998
HGNC 21769
MGI 1918985
PubMed 20180869
UniProt Q9UFC0
Ahighly conserved, leucine-rich repeats and WD40 repeat domain-containing protein 1 (LRWD1) or ORC-associated (ORCA) in human cells that interacts with ORC and modulates chromatin association of ORC. ORCA colocalizes with ORC and shows similar cell-cycle dynamics. ORCA efficiently recruits ORC to chromatin. Depletion of ORCA in human primary cells and embryonic stem cells results in loss of ORC association to chromatin, concomitant reduction of MCM binding, and a subsequent accumulation in G1 phase. Reading specific trimethyl-lysine sites by specialized complexes appears to be a widespread mechanism to mediate gene expression. The ORC complex, including LRWD1, binds to the three most prominent transcriptional repressive lysine methylation sites.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeats And WD Repeat Domain Containing Protein 1 (LRWD1) ELISA Kit Customized Service Offer
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  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
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  12. "Nucleosome-interacting proteins regulated by DNA and histone methylation."Cell 143:470-484(2010) [PubMed] [Europe PMC] [Abstract]
  13. "A WD-repeat protein stabilizes ORC binding to chromatin."Mol. Cell 40:99-111(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Orc2 protects ORCA from ubiquitin-mediated degradation."Cell Cycle 11:3578-3589(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing."J. Biol. Chem. 287:15024-15033(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation."Mol. Cell. Biol. 32:3107-3120(2012) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]