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Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17)

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TEM4; p164-RhoGEF; Rho-Specific Guanine-Nucleotide Exchange Factor 164 kDa; Tumor Endothelial Marker 4

Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17)
CCC Q988
HGNC 21726
MGI 2673002
RGD 1309890
UniProt Q96PE2
In contrast with the full-length p164, expression of p164-DeltaC and p164-DeltaN strongly induced actin stress fibre formation and activated serum response factor-mediated and Rho-dependent gene transcription. Interestingly, p164-DeltaN2, a mutant containing the C-terminus but having a defective DH domain, bound to p164-DeltaC and suppressed the p164-DeltaC-induced gene transcription. Overexpression of the full-length p164 inhibited M muscarinic receptor-induced gene transcription, whereas co-expression with Gbeta gamma dimers induced transcriptional activity.
p164-RhoGEF is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. Apparently, its N- and C-termini interact with each other, thereby inhibiting its GEF activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho Guanine Nucleotide Exchange Factor 17 (ARHGEF17) ELISA Kit Customized Service Offer
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