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Transmembrane Protein 8B (TMEM8B)

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C9orf127; NAG-5; NGX6; Nasopharyngeal Carcinoma Expressed 6

Transmembrane Protein 8B (TMEM8B)
CCC Q961
HGNC 21427
MGI 2441680
PubMed 21464545
UniProt A6NDV4
Wiki C9orf127
NGX6, NAG-7 and BRD7 genes are tumor related genes, which have been newly cloned by positional candidate cloning strategy. The down-regulation of NGX6 may be closely associated with tumorigenesis and metastasis of colorectal carcinoma. NGX6 and its mutants were distributed on the plasma membrane, nuclear membrane, endoplasmic reticulum membrane, and other membrane structures in the cytosol. The deleted domains did not affect its distribution in 5-8F cells. NGX6 could increase the adhesion but inhibited the proliferation, growth and migration of 5-8F cells. The epidermal growth factor-like domain and CYTO region were found to be important for NGX6 to modulate cell adhesion, and CYTO was found to be essential for NGX6 involved in the regulation of growth, proliferation, and migration of 5-8F cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 8B (TMEM8B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 8B (TMEM8B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 8B (TMEM8B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 8B (TMEM8B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 8B (TMEM8B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 8B (TMEM8B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 8B (TMEM8B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 8B (TMEM8B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 8B (TMEM8B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 8B (TMEM8B) ELISA Kit Customized Service Offer
  1. "Proteomic detection of changes in protein synthesis induced by NGX6 transfected in human nasopharyngeal carcinoma cells."J. Protein Chem. 20:265-271(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells."Carcinogenesis 26:281-291(2005) [PubMed] [Europe PMC] [Abstract]
  6. "NGX6 gene inhibits cell proliferation and plays a negative role in EGFR pathway in nasopharyngeal carcinoma cells."J. Cell. Biochem. 95:64-73(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The role of NGX6 and its deletion mutants in the proliferation, adhesion and migration of nasopharyngeal carcinoma 5-8F cells."Oncology 71:273-281(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The expression of ezrin in NPC and its interaction with NGX6, a novel candidate suppressor."Cancer Sci. 98:341-349(2007) [PubMed] [Europe PMC] [Abstract]