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Akirin 2 (AKIRIN2)

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C6orf166

Akirin 2 (AKIRIN2)
CCC Q960
HGNC 21407
MGI 1889364
PubMed 24033432
RGD 1307791
UniProt Q53H80
Wiki C6orf166
The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappaB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappaB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Akirin 2 (AKIRIN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Akirin 2 (AKIRIN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Akirin 2 (AKIRIN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Akirin 2 (AKIRIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Akirin 2 (AKIRIN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Akirin 2 (AKIRIN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Akirin 2 (AKIRIN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Akirin 2 (AKIRIN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Akirin 2 (AKIRIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Akirin 2 (AKIRIN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Akirin 2 (AKIRIN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Akirin 2 (AKIRIN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Akirin 2 (AKIRIN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Akirin 2 (AKIRIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Akirin 2 (AKIRIN2) ELISA Kit Customized Service Offer
  1. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in Drosophila and mice."Nat. Immunol. 9:97-104(2008) [PubMed] [Europe PMC] [Abstract]
  5. ErratumNat. Immunol. 9:216-216(2008)
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]