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RWD Domain Containing Protein 3 (RWDD3)

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RSUME; RWD domain-containing sumoylation enhancer

RWD Domain Containing Protein 3 (RWDD3)
CCC Q957
HGNC 21393
MGI 1920420
PubMed 22877241
UniProt Q9Y3V2
Wiki RWDD3
RWDD3, a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune–inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RWD Domain Containing Protein 3 (RWDD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RWD Domain Containing Protein 3 (RWDD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RWD Domain Containing Protein 3 (RWDD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RWD Domain Containing Protein 3 (RWDD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for RWD Domain Containing Protein 3 (RWDD3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RWD Domain Containing Protein 3 (RWDD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RWD Domain Containing Protein 3 (RWDD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RWD Domain Containing Protein 3 (RWDD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RWD Domain Containing Protein 3 (RWDD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for RWD Domain Containing Protein 3 (RWDD3) ELISA Kit Customized Service Offer
  1. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia."Cell 131:309-323(2007) [PubMed] [Europe PMC] [Abstract]
  6. "RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells."Endocr. Relat. Cancer 19:13-27(2012) [PubMed] [Europe PMC] [Abstract]
  7. "RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity."Mol. Cell. Biol. 33:2116-2127(2013) [PubMed] [Europe PMC] [Abstract]
  8. "In silico structural and functional characterization of the RSUME splice variants."PLoS ONE 8:E57795-E57795(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of the RWD domain of human RWD domain containing protein 3."Submitted (AUG-2007) to the PDB data bank