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3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1)

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er-cHL; Endoplasmic reticulum 3-hydroxymethyl-3-methylglutaryl-CoA lyase; 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic

3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1)
CCC Q952
HGNC 21359
MGI 2446108
PubMed 22865860
RGD 1565090
UniProt Q8TB92
Ketogenic metabolism has been associated with mitochondria, which contain HMG-CoA synthase, HMG-CoA lyase, and 3-hydroxybutyrate dehydrogenase.
A bioinformatic approach has identified several mammalian proteins, designated as HMGCLL1 (HMG-CoA lyase like), as putative members of the HMG-CoA lyase family. These proteins are characterized by a unique 37 residue N-terminus that contains a potential myristoylation site but not a mitochondrial leader sequence. In order to test the function of these proteins, full length human HMGCLL1 coding sequence has been isolated from a MGC repository clone and introduced into expression vectors. HMGCLL1 could function as an extramitochondrial HMG-CoA lyase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3-Hydroxymethyl-3-Methylglutaryl Coenzyme A Lyase Like Protein 1 (HMGCLL1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of an extramitochondrial human 3-Hydroxy-3-methylglutaryl-CoA lyase."J. Biol. Chem. 287:33227-33236(2012) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of a novel HMG-CoA Lyase enzyme with a dual location in endoplasmic reticulum and cytosol."J. Lipid Res. 53:2046-2056(2012) [PubMed] [Europe PMC] [Abstract]