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Alpha-Tubulin Acetyltransferase 1 (aTAT1)

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C6orf134; MEC17; Acetyltransferase mec-17 homolog; Alpha-tubulin N-acetyltransferase 1

Alpha-Tubulin Acetyltransferase 1 (aTAT1)
CCC Q925
HGNC 21186
MGI 1913869
PubMed 23720746
RGD 1303066
UniProt Q5SQI0
MEC-17, a protein related to the Gcn5 histone acetyltransferases and required for the function of touch receptor neurons in Caenorhabditis elegans, acts as a K40-specific acetyltransferase for alpha-tubulin.
In vitro, MEC-17 exclusively acetylates K40 of alpha-tubulin. Disruption of the Tetrahymena MEC-17 gene phenocopies the K40R alpha-tubulin mutation and makes microtubules more labile. Depletion of MEC-17 in zebrafish produces phenotypes consistent with neuromuscular defects. In C. elegans, MEC-17 and its paralogue W06B11.1 are redundantly required for acetylation of MEC-12 alpha-tubulin, and contribute to the function of touch receptor neurons partly via MEC-12 acetylation and partly via another function, possibly by acetylating another protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alpha-Tubulin Acetyltransferase 1 (aTAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alpha-Tubulin Acetyltransferase 1 (aTAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alpha-Tubulin Acetyltransferase 1 (aTAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alpha-Tubulin Acetyltransferase 1 (aTAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-Tubulin Acetyltransferase 1 (aTAT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alpha-Tubulin Acetyltransferase 1 (aTAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alpha-Tubulin Acetyltransferase 1 (aTAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alpha-Tubulin Acetyltransferase 1 (aTAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alpha-Tubulin Acetyltransferase 1 (aTAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-Tubulin Acetyltransferase 1 (aTAT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alpha-Tubulin Acetyltransferase 1 (aTAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alpha-Tubulin Acetyltransferase 1 (aTAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alpha-Tubulin Acetyltransferase 1 (aTAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alpha-Tubulin Acetyltransferase 1 (aTAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-Tubulin Acetyltransferase 1 (aTAT1) ELISA Kit Customized Service Offer
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  10. "Structure of the alpha-tubulin acetyltransferase, alphaTAT1, and implications for tubulin-specific acetylation."Proc. Natl. Acad. Sci. U.S.A. 109:19655-19660(2012) [PubMed] [Europe PMC] [Abstract]