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Splicing Factor 3B Subunit 5 (SF3B5)

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SF3b10; Ysf3; Pre-mRNA-splicing factor SF3b 10 kDa subunit

Splicing Factor 3B Subunit 5 (SF3B5)
CCC Q916
HGNC 21083
MGI 1913375
PubMed 12234937
RGD 1586993
UniProt Q9BWJ5
Wiki SF3B5
Mass spectrometry was used to identify novel proteins associated with the human 17S U2 snRNP and one of its stable subunits, SF3b. Several additional proteins were identified, demonstrating that 17S U2 snRNPs are significantly more complex than previously thought. Two of the newly identified proteins, namely the DEAD-box proteins SF3b125 and hPrp5 were characterized further.
SF3b5 is a 10 kDa subunit of the splicing factor SF3b. SF3b associates with the splicing factor SF3a and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex. SF3b5 and SF3b14b are also thought to facilitate the interaction of U2 with the branch site . Also included in this entry is RDS3 complex subunit 10, another protein involved in mRNA splicing.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Splicing Factor 3B Subunit 5 (SF3B5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Splicing Factor 3B Subunit 5 (SF3B5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Splicing Factor 3B Subunit 5 (SF3B5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Splicing Factor 3B Subunit 5 (SF3B5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Splicing Factor 3B Subunit 5 (SF3B5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Splicing Factor 3B Subunit 5 (SF3B5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Splicing Factor 3B Subunit 5 (SF3B5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Splicing Factor 3B Subunit 5 (SF3B5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Splicing Factor 3B Subunit 5 (SF3B5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Splicing Factor 3B Subunit 5 (SF3B5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Splicing Factor 3B Subunit 5 (SF3B5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Splicing Factor 3B Subunit 5 (SF3B5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Splicing Factor 3B Subunit 5 (SF3B5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Splicing Factor 3B Subunit 5 (SF3B5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Splicing Factor 3B Subunit 5 (SF3B5) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein."EMBO J. 21:4978-4988(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular architecture of the multiprotein splicing factor SF3b."Science 300:980-984(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract]
  7. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]