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Rhomboid Family, Member 2 (RHBDF2)

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RHBDL6; RHBDL5; Rhomboid, Veinlet-Like 6; Inactive rhomboid protein 2; Rhomboid veinlet-like protein 5

Rhomboid Family, Member 2 (RHBDF2)
CCC Q884
HGNC 20788
MGI 2442473
PubMed 22638770
RGD 1309699
UniProt Q6PJF5
Wiki RHBDF2
RHBDF2 was shown to be up regulated in tumors and silencing of RHBDF2 inhibited TNFα response, scratch wound closure and tube formation. In zebrafish RHBDF2 was shown to be expressed, although not exclusively, in endothelial cells. RHBDF2 morpholinos inhibited intersomitic vessel formation and showed aberrant arteriogenesis, whereas no effects were observed in the venous system. CLEC14A forms a complex with RHBDL2 and is subsequently cleaved by RHBDL2 in the transmembrane region, resulting in inactivation of the protein. RHBDL2 itself is regulated by RHBDF2, which specifically associates with RHBDL2 to inhibit its activity. In conclusion, Bicknell identified a new signaling pathway in which RHBDF2, RHBDL2 and CLEC14A regulate tumor angiogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rhomboid Family, Member 2 (RHBDF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rhomboid Family, Member 2 (RHBDF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rhomboid Family, Member 2 (RHBDF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rhomboid Family, Member 2 (RHBDF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rhomboid Family, Member 2 (RHBDF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rhomboid Family, Member 2 (RHBDF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rhomboid Family, Member 2 (RHBDF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rhomboid Family, Member 2 (RHBDF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rhomboid Family, Member 2 (RHBDF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rhomboid Family, Member 2 (RHBDF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rhomboid Family, Member 2 (RHBDF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rhomboid Family, Member 2 (RHBDF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rhomboid Family, Member 2 (RHBDF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rhomboid Family, Member 2 (RHBDF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rhomboid Family, Member 2 (RHBDF2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  6. "RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome."Am. J. Hum. Genet. 90:340-346(2012) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]