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WD Repeat And FYVE Domain Containing Protein 3 (WDFY3)

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ALFY; ZFYVE25; Autophagy-linked FYVE protein

WD Repeat And FYVE Domain Containing Protein 3 (WDFY3)
CCC Q876
HGNC 20751
MGI 1096875
PubMed 23045723
RGD 1307097
UniProt Q8IZQ1
Wiki WDFY3
WDFY3 encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. The expression profiles of all the genes among 10 human tissues, 8 brain regions, spinal cord, fetal brain and fetal liver were also examined by reverse transcription-coupled polymerase chain reaction, products of which were quantified by enzyme-linked immunosorbent assay.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat And FYVE Domain Containing Protein 3 (WDFY3) ELISA Kit Customized Service Offer
  1. "Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes."J. Cell Sci. 117:4239-4251(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy."Autophagy 6:330-344(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Functional interaction between sequestosome-1/p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts."Biochem. Biophys. Res. Commun. 402:543-548(2010) [PubMed] [Europe PMC] [Abstract]
  10. "The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy."Mol. Cell 38:265-279(2010) [PubMed] [Europe PMC] [Abstract]
  11. "TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy."Autophagy 9:1955-1964(2013) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures."EMBO Rep. 15:557-565(2014) [PubMed] [Europe PMC] [Abstract]