Cytochrome P450 4A22 (CYP4A22)
[Edit]CYPIVA22; Cytochrome P450, Family 4, Subfamily A, Polypeptide 22; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase
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CYP4A22 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33
The CYP4A fatty acid monooxygenases oxidize endogenous arachidonic acid to 20-hydroxyeicosatetraenoic acid that acts as a regulator of blood pressure. Among the isoforms of the CYP4A subfamily, the human CYP4A22 was recently identified. Allelic variants of the human CYP4A22 gene exist and speculated that some of these variants may be functionally relevant.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cytochrome P450 4A22 (CYP4A22) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cytochrome P450 4A22 (CYP4A22) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cytochrome P450 4A22 (CYP4A22) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cytochrome P450 4A22 (CYP4A22) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cytochrome P450 4A22 (CYP4A22) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cytochrome P450 4A22 (CYP4A22) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cytochrome P450 4A22 (CYP4A22) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cytochrome P450 4A22 (CYP4A22) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cytochrome P450 4A22 (CYP4A22) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cytochrome P450 4A22 (CYP4A22) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cytochrome P450 4A22 (CYP4A22) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cytochrome P450 4A22 (CYP4A22) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cytochrome P450 4A22 (CYP4A22) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cytochrome P450 4A22 (CYP4A22) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cytochrome P450 4A22 (CYP4A22) | ELISA Kit Customized Service Offer |
- "Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein."Arch. Biochem. Biophys. 378:333-339(2000) [PubMed] [Europe PMC] [Abstract]
- "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension."Circulation 111:63-69(2005) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population."Mutat. Res. 599:98-104(2006) [PubMed] [Europe PMC] [Abstract]