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Histone Cluster 3, H2bb (HIST3H2BB)

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Histone Cluster 3, H2bb (HIST3H2BB)
CCC Q854
HGNC 20514
MGI 1922442
PubMed 12408966
RGD 1583885
UniProt Q8N257
Wiki HIST3H2BB
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.HIST3H2BB is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 3, H2bb (HIST3H2BB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 3, H2bb (HIST3H2BB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 3, H2bb (HIST3H2BB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 3, H2bb (HIST3H2BB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 3, H2bb (HIST3H2BB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 3, H2bb (HIST3H2BB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 3, H2bb (HIST3H2BB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 3, H2bb (HIST3H2BB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 3, H2bb (HIST3H2BB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 3, H2bb (HIST3H2BB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 3, H2bb (HIST3H2BB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 3, H2bb (HIST3H2BB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 3, H2bb (HIST3H2BB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 3, H2bb (HIST3H2BB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 3, H2bb (HIST3H2BB) ELISA Kit Customized Service Offer
  1. "The human and mouse replication-dependent histone genes."Genomics 80:487-498(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative proteomic analysis of post-translational modifications of human histones."Mol. Cell. Proteomics 5:1314-1325(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase."Cell 113:507-517(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation."Mol. Cell 20:601-611(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Inhibition of core histones acetylation by carcinogenic nickel(II)."Mol. Cell. Biochem. 279:133-139(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II."Cell 125:703-717(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry."Mol. Cell. Proteomics 5:541-552(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification."Cell 146:1016-1028(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation."Mol. Cell 43:132-144(2011) [PubMed] [Europe PMC] [Abstract]
  13. "USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing."Genes Dev. 27:1581-1595(2013) [PubMed] [Europe PMC] [Abstract]