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Spindle And Kinetochore Associated Complex Subunit 3 (SKA3)

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C13orf3; RAMA1

Spindle And Kinetochore Associated Complex Subunit 3 (SKA3)
CCC Q825
HGNC 20262
MGI 3041235
RGD 1307201
UniProt Q8IX90
SKA3 encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromosome segregation and cell division. Alternative splicing results in multiple transcript variants.
C13orf3 localises to centrosomes, the mitotic spindle, kinetochores, spindle midzone, and the cleavage furrow during cell division and is specifically phosphorylated during mitosis. Furthermore, C13orf3 is required for centrosome integrity and anaphase onset. Proteomic analyses identify C13orf3 (Ska3) as a new component of the Ska complex and show a direct interaction with a regulatory subunit of the protein phosphatase PP2A.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spindle And Kinetochore Associated Complex Subunit 3 (SKA3) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility."Dev. Cell 16:374-385(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3."EMBO J. 28:1442-1452(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]