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Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2)

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LL5beta; LL5b

Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2)
CCC Q740
HGNC 29573
MGI 2444981
PubMed 20513769
RGD 1591402
UniProt Q86SQ0
Wiki PHLDB2
LL5-beta bound immobilized PtdIns(3,4,5)P3 and was released by free competing PtdIns(3,4,5)P3, but not by any other phosphoinositides tested. In the presence of serum, LL5-beta was expressed in the cytosol of transfected porcine aorta endothelial cells. However, serum starvation, low PtdIns(3,4,5)P3 levels, or expression of a PDGF-beta receptor (PDGFRB) mutant unable to activate PI3K activity led to redistribution of a significant proportion of LL5-beta to intracellular vesicles. PH domain mutants of LL5-beta could not bind PtdIns(3,4,5)P3 and were constitutively localized to vesicles. Increased PtdIns(3,4,5)P3 levels redirected LL5-beta primarily to the cytosol. High PtdIns(3,4,5)P3 levels due to PDGF stimulation resulted in association of LL5-beta with the plasma membrane. .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleckstrin Homology Like Domain Family B, Member 2 (PHLDB2) ELISA Kit Customized Service Offer
  1. "LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin."J. Biol. Chem. 278:1328-1335(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities."Biochem. J. 351:19-31(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]