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Histone Cluster 1, H2ba (HIST1H2BA)

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STBP; TSH2B; H2BFU; H2B Histone Family, Member U; Testis-specific histone H2B

Histone Cluster 1, H2ba (HIST1H2BA)
CCC Q711
HGNC 18730
MGI 2448375
PubMed 12408966
RGD 3855
UniProt Q96A08
Wiki HIST1H2BA
By sequencing histones purified from human sperm, followed by database analysis, Zalensky et al. (2002) identified HIST1H2BA, which they called TSH2B. The deduced 127-amino acid protein shares 85% identity with somatic H2B.1, but it has more potential phosphorylation and myristoylation sites.
TSH2B shares 95% and 93% amino acid identity with mouse and rat Tsh2b, respectively. RT-PCR detected TSH2B expression exclusively in testis. Using several extraction procedures, Zalensky et al. (2002) found that TSH2B was relatively tightly bound to sperm chromatin. Immunolocalization detected TSH2B in a punctate localization in mature sperm, but it was not part of the telomere-binding complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2ba (HIST1H2BA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2ba (HIST1H2BA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2ba (HIST1H2BA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2ba (HIST1H2BA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2ba (HIST1H2BA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2ba (HIST1H2BA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2ba (HIST1H2BA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2ba (HIST1H2BA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2ba (HIST1H2BA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2ba (HIST1H2BA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2ba (HIST1H2BA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2ba (HIST1H2BA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2ba (HIST1H2BA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2ba (HIST1H2BA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2ba (HIST1H2BA) ELISA Kit Customized Service Offer
  1. "Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization."J. Biol. Chem. 277:43474-43480(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The human and mouse replication-dependent histone genes."Genomics 80:487-498(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation."Mol. Cell 20:601-611(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Inhibition of core histones acetylation by carcinogenic nickel(II)."Mol. Cell. Biochem. 279:133-139(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II."Cell 125:703-717(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification."Cell 146:1016-1028(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation."Mol. Cell 43:132-144(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Histone variants and their post-translational modifications in primary human fat cells."PLoS ONE 6:E15960-E15960(2011) [PubMed] [Europe PMC] [Abstract]