≡

WW Domain Containing Adaptor With Coiled Coil Protein (WAC)

[Edit]

Wwp4

WW Domain Containing Adaptor With Coiled Coil Protein (WAC)
CCC Q601
HGNC 17327
MGI 2387357
PubMed 11827461
UniProt Q9BTA9
WAC contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. WAC, is located in human chromosome 10p11.2-10p12.1. A Drosophila melanogaster WAC homolog was identified as a Rosetta stone protein. Domain fusion analysis of the Rosetta stone protein linked WAC to splicing factor SNRP70. WAC existed mainly in a tyrosine-phosphorylated form. Immunofluorescence analysis colocalized WAC with SC35, the marker for pre-mRNA splicing machinery.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Containing Adaptor With Coiled Coil Protein (WAC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Containing Adaptor With Coiled Coil Protein (WAC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Containing Adaptor With Coiled Coil Protein (WAC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Containing Adaptor With Coiled Coil Protein (WAC) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Containing Adaptor With Coiled Coil Protein (WAC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Containing Adaptor With Coiled Coil Protein (WAC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Containing Adaptor With Coiled Coil Protein (WAC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Containing Adaptor With Coiled Coil Protein (WAC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Containing Adaptor With Coiled Coil Protein (WAC) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Containing Adaptor With Coiled Coil Protein (WAC) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC."EMBO J. 31:1931-1946(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  17. "WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription."Mol. Cell 41:384-397(2011) [PubMed] [Europe PMC] [Abstract]