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ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP)

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BART1; BART; Binder Of Arl2; Binder of ARF2 protein 1

ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP)
CCC Q587
HGNC 17146
MGI 1349429
PubMed 23849777
RGD 1561471
UniProt Q9Y2Y0
ARL2BP is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity.The downstream effector for Arl2, Binder of Arl 2 (BART) has no known function but, together with Arl2, can enter mitochondria and bind the adenine nucleotide transporter.
BART forms a novel fold composed of six alpha-helices that form three interlocking "L" shapes. Analysis of the backbone dynamics reveals that the protein is highly anisotropic and that the loops between the central helices are dynamic. The regions involved in the binding of Arl2 were mapped onto the surface of BART and are found to localize to these loop regions. BART has faces of differing charge and structural elements, which may explain how it can interact with other proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor Like 2 Binding Protein (ARL2BP) ELISA Kit Customized Service Offer
  1. "The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning, and initial characterization."J. Biol. Chem. 274:27553-27561(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins."J. Biol. Chem. 276:22826-22837(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C."J. Biol. Chem. 277:14629-14634(2002) [PubMed] [Europe PMC] [Abstract]
  6. "ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter."Mol. Biol. Cell 13:71-83(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Arl2 and Arl3 regulate different microtubule-dependent processes."Mol. Biol. Cell 17:2476-2487(2006) [PubMed] [Europe PMC] [Abstract]
  8. "BART is essential for nuclear retention of STAT3."Int. Immunol. 20:395-403(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function."J. Biol. Chem. 284:992-999(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector."Structure 17:602-610(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosa."Am. J. Hum. Genet. 93:321-329(2013) [PubMed] [Europe PMC] [Abstract]