Protein GR6 (GR6)

GR6 encoding putative GR6 protein, consisted of 3 exons and contained 4 CpG islands by sequence analysis. It was predicted that putative GR6 protein included one protein kinase C phosphorylation site, one casein kinase II phosphorylation site, and three N-myristoylation sites. PSORT II software analysis predicted that putative GR6 protein was located in nucleus (reliability: 76.7%). At the level of mRNA, the expression of GR6 gene was high in normal mucosa, moderate in mucosa adjacent to cancer and adenoma tissue, low in colorectal carcinoma tissue.

GR6 may predictably function as an important nuclear signal transduction molecule. Decreased expression of GR6 gene may play an important role in the initiation and promotion of colorectal neoplasia.