≡

Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18)

[Edit]

P114-RhoGEF; SA-RhoGEF; 114 kDa Rho-specific guanine nucleotide exchange factor; Septin-associated RhoGEF

Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18)
CCC Q585
HGNC 17090
MGI 2142567
PubMed 23698346
RGD 1311448
UniProt Q6ZSZ5
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs).
ARHGEF18 is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho/Rac Guanine Nucleotide Exchange Factor 18 (ARHGEF18) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor."Biochem. J. 352:319-325(2000) [PubMed] [Europe PMC] [Abstract]
  6. "A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2."Genomics 73:203-210(2001) [PubMed] [Europe PMC] [Abstract]
  7. "G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production."Circ. Res. 93:848-856(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Cytoskeletal modification of Rho guanine nucleotide exchange factor activity: identification of a Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin."Oncogene 24:65-76(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]