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Ribosomal RNA Processing 9 Homolog (RRP9)

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RNU3IP2; U3-55K; RNA, U3 Small Nucleolar Interacting Protein 2; U3 small nucleolar ribonucleoprotein-associated 55 kDa protein

Ribosomal RNA Processing 9 Homolog (RRP9)
CCC Q566
HGNC 16829
MGI 2384313
PubMed 9418896
RGD 1307881
UniProt O43818
Wiki RRP9
The eukaryotic nucleolus contains a large number of small RNA molecules (snoRNAs) which, in the form of small nucleolar ribonucleoprotein complexes (snoRNPs), are involved in the processing and modification of pre-rRNA. The most abundant and one of the best-conserved snoRNAs is the U3 RNA. Previously, the U3 snoRNPwas purified from CHO cells, and three proteins of 15, 50, and 55 kDa were found to copurify with the U3 snoRNA. The isolated cDNA codes for a novel nucleolar protein which is specifically associated with the U3 snoRNA. hU3-55k, is the first characterized U3 snoRNP-specific protein from humans. hU3-55k is a new member of the family of WD-40 repeat proteins and is conserved throughout evolution. It appears that the C-terminal end of hU3-55k is required for nucleolar localization and U3 snoRNA binding.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal RNA Processing 9 Homolog (RRP9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal RNA Processing 9 Homolog (RRP9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal RNA Processing 9 Homolog (RRP9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal RNA Processing 9 Homolog (RRP9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal RNA Processing 9 Homolog (RRP9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal RNA Processing 9 Homolog (RRP9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal RNA Processing 9 Homolog (RRP9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal RNA Processing 9 Homolog (RRP9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal RNA Processing 9 Homolog (RRP9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal RNA Processing 9 Homolog (RRP9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal RNA Processing 9 Homolog (RRP9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal RNA Processing 9 Homolog (RRP9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal RNA Processing 9 Homolog (RRP9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal RNA Processing 9 Homolog (RRP9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal RNA Processing 9 Homolog (RRP9) ELISA Kit Customized Service Offer
  1. "cDNA cloning and characterization of the human U3 small nucleolar ribonucleoprotein complex-associated 55-kilodalton protein."Mol. Cell. Biol. 18:488-498(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Interaction of the U3-55k protein with U3 snoRNA is mediated by the box B/C motif of U3 and the WD repeats of U3-55k."Nucleic Acids Res. 28:3462-3471(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The hU3-55K protein requires 15.5K binding to the box B/C motif as well as flanking RNA elements for its association with the U3 small nucleolar RNA in Vitro."J. Biol. Chem. 277:48490-48500(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of RRP9 WD40 repeats."Submitted (APR-2013) to the PDB data bank
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]