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Leucine Rich Repeat Containing Protein 6 (LRRC6)

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TSLRP; LRTP; Protein tilB homolog; Leucine-rich testis-specific protein; Testis-specific leucine-rich repeat protein

Leucine Rich Repeat Containing Protein 6 (LRRC6)
CCC Q549
HGNC 16725
MGI 1859553
PubMed 23527195
UniProt Q86X45
Leucine-rich repeat-containing 3B (LRRC3B) is an evolutionarily highly conserved leucine-rich repeat-containing protein, LRRC6 may be involved in spermatocytogenesis or prophase of meiosis. In a proteomics analysis, murine Lrrc6 was found in the photoreceptor-sensory complex consisting of the outer seg- ment and its cytoskeleton.
The human homolog (LRRC6) was identified as a testis-specific factor. Analysis of the TilB protein domain structure suggests the presence of two highly conserved domains separated by a less conserved coiled-coiled region. The protein contains an N-terminal leucine-rich repeat (LRR) domain with four clear repeats from residues 16 to 107 and two additional repeats up to residue 164 that align less well with the consensus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeat Containing Protein 6 (LRRC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeat Containing Protein 6 (LRRC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeat Containing Protein 6 (LRRC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeat Containing Protein 6 (LRRC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeat Containing Protein 6 (LRRC6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeat Containing Protein 6 (LRRC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeat Containing Protein 6 (LRRC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeat Containing Protein 6 (LRRC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeat Containing Protein 6 (LRRC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeat Containing Protein 6 (LRRC6) ELISA Kit Customized Service Offer
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Loss-of-function mutations in LRRC6, a gene essential for proper axonemal assembly of inner and outer dynein arms, cause primary ciliary dyskinesia."Am. J. Hum. Genet. 91:958-964(2012) [PubMed] [Europe PMC] [Abstract]
  3. "Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia."Eur. Respir. J. 44:1579-1588(2014) [PubMed] [Europe PMC] [Abstract]